Different mechanisms regarding the beneficial effects of Curcumin on renal function were also reported: reducing pro-inflammatory cytokines (TNF-alpha, IL-6) [71], reducing growth factors synthesis (TGFβ, VEGF, and PDGF), which contribute to renal failure [72], xanthine oxidase blocking with oxidative stress attenuation [72]. The gene discussed is VEGFA; the disease is Renal insufficiency.