Due to the limited efficacy of interferon on HDV-CH, several studies evaluated the efficacy of peg-IFN-α combined with HBV nucleo(s)tide analogues [110,111]: lamivudine [108,112], famciclovir [113], adefovir [101], tenofovir [114] and entecavir [107]. This evidence concerns the gene IFNA1 and cyclic hematopoiesis.