HDV chronic infection, detectable by the persistence of antibody to HDV and HDV RNA or HD-Ag in serum for at least 6 months after HDV infection, leads to chronic hepatitis Delta (HDV-CH), a disease more severe than HBV-CH, with higher aminotransferase levels and increased rates of fibrosis progression [66,67]. The gene discussed is RENBP; the disease is cyclic hematopoiesis.