A diversity of exogenous and endogenous stimuli are involved in complex molecular and cellular changes, including oxidative DNA damage and participation in cancer development [39], and different studies have explored the potential of probiotics (L. casei and L. rhamnosus) as cell-free supernatants to inhibit colon cancer cell invasion [40], the antiproliferative and apoptotic effects driven by L. casei ATCC 393 against experimental colon cancer [41], or Lactobacilli strains as modulators of Fiaf gene expression in human epithelial intestinal cells [42]. This evidence concerns the gene ANGPTL4 and cancer.