Through the calculation of interaction between the COVID-19 spike protein and ACE2, the total interaction energy (absolute value) was 158.342 kcal/mol, which was contributed by GLN24, ASP30, LYS31, HIS34, GLU35, ASP38, TYR41, GLN42, MET82, TYR83, LYS353, and GLY354 (Table 2 and Supplementary Materials, Figure S5). The gene discussed is ACE2; the disease is COVID-19.