Although this dysbiosis is associated primarily with CFTR dysfunction, several acquired factors, such as repeated antibiotic exposures, high-calorie diets, and other medications (acid-suppressive medications, opioids, anticholinergic agents, posttransplant immunosuppressive medications, etc.), may further perpetuate the gut dysbiosis in CF [18,30,40,42,43]. The gene discussed is CFTR; the disease is cystic fibrosis.