Since cell shrinkage is usually one of the first signs that PC are beginning to age [70], we put the hypothesis that the overexpression of both miR204-5p and VEGF eliminated the neuroprotective effects of VEGFR-1 and -2 in mature PC, which inevitably initiated the ageing process and, therefore, a reduction of total dendritic length in the affected cells. The gene discussed is FLT1; the disease is pachyonychia congenita.