For instance, the nuclear accumulation of p53 protein was frequently seen in papillary adenocarcinoma, well-to-moderately differentiated tubular adenocarcinoma and poorly differentiated adenocarcinoma with solid nests or focal tubular structures but was rarely seen in signet-ring cell carcinoma, mucinous adenocarcinoma, or poorly differentiated adenocarcinoma growing in a scattered manner [136,137]. This evidence concerns the gene TP53 and adenocarcinoma.