However, a year later, Drs. Yokosaki and Tahara showed that, even in primary tumors, TP53 was mutated (codons G117A, C141T, W158C, M160K, G226A, D228T, G245S, I254T, and V272E) in 56% of the samples, including early-stage cancers I and II [30] (Figure 3). The gene discussed is TP53; the disease is cancer.