DENND1A and polycystic ovary syndrome: Since Ras-related protein Rab-5B (RAB5B) interacts with the DENN domain and contributes to the insulin and MAPK signaling pathways, then it is expected that DENND1A.V2 may influence insulin or luteinizing hormone (LH)-receptor turnover and further affect ovarian function in PCOS patients [75,76].