ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myeloid leukemia (CML) in adults is underlined by a reciprocal chromosomal translocation between chromosomes 9 and 22, t(9;22), resulting in the production of the BCR/ABL1 fusion gene, whose expression gives the BCR/ABL1 protein, a constitutive tyrosine kinase activating cancer-related signaling pathways [62].