OAC activates the Nrf2/glutathione pathway through PI3K/Akt [38], and induces oxidized protein-mediated endoplasmic reticulum stress and autophagy [39] to protect human neuroblastoma SH-SY5Y cells against neurotoxin 6-hydroxydopamine (6-OHDA) toxicity. This evidence concerns the gene NFE2L2 and neuroblastoma.