Likewise, we observed an increased colocalization between Cx43 and GFAP during BCC extravasation into the brain, mainly in non-peritumoral astrocytes This result suggests that, when BCCs colonize the brain, reactive astrocytes expressing Cx43 are recruited, which may promote BCCs proliferation and survival [63], via Cx43-mediated crosstalk. Here, GFAP is linked to skin basal cell carcinoma.