EZR and cancer: Because this study was conducted in 2D, it does not provide details on whether the invadopodial β1-integrin/ILK/NHE1/p(T567)-ezrin/NHERF1 signalsome is constitutively present and/or equally functional during essential steps of the metastatic cascade, i.e., cancer cell local invasion, intravasation and extravasation.