NUP214 and Alzheimer disease: The perturbations in the plasticity of excitatory hippocampal synapses observed during ageing can be a consequence of deregulation in AMPAR trafficking [215], which is modulated by CaMKII [216,217,218] and CaN [219,220], and of alterations in CaV1.2 function, that are found in several neurologic disorders including PD and AD [221].