MAPT and Alzheimer disease: The authors demonstrated the existence of a molecular complex consisting of GSKIP, RII-based PKA, GSK3β and Tau (tethered to GSK3β) that enhances the cAMP/PKA signalling, resulting in increased Tau phosphorylation at distinct PKA-dependent phosphorylation sites (Ser214, Ser262, and Ser409) during AD pathogenesis [276].