MANF and kidney disorder: The ER stress-inducible, secreted ER chaperones, including MANF, ERdj3, ERdj4, PDIA3, as well as other ER stress-dependent highly soluble proteins, including CRELD2 and angiogenin (Table 1), may provide a valuable tool in the investigation of disease pathogenesis, early diagnosis, risk stratification, treatment response monitoring, and development of targeted therapies for rare kidney diseases.