The concentration of placental exosomes in the blood of pregnant women is higher with GDM compared to normal pregnant women [109]: in the first trimester, the concentration of PLAP+-exosomes was 1.6-fold higher (81 ± 7 vs. 128 ± 14 pg/mL for normal and GDM, respectively), in the second trimester it was 1.5-fold higher (188 ± 14 vs. 282 ± 24 pg/mL for normal and GDM, respectively), and the third trimester it was 1.3-fold higher (304 ± 29 vs. 418 ± 57 pg/mL for normal and GDM, respectively). Here, ALPP is linked to gestational diabetes.