The primary tumor showed histopathological characteristics of a poorly differentiated, Schwann cell-poor stroma with a proliferation rate (MIB1, E3 ubiquitin-protein ligase) of 40%, a low mitosis karyorrhexis index (INPC, International Neuroblastoma Pathology Classification) and <5% differentiating cells. This evidence concerns the gene UBE2E3 and neoplasm.