PFKFB1 encodes the isoenzyme identified in fetal tissue and the liver; PFKFB2 encodes a protein expressed mainly in the heart and kidney; the product of PFKFB3 occurs in adipose tissue, the brain, and frequently in cancer cells; and PFKFB4 is almost exclusively significantly expressed in testes and tumor cells [11]. This evidence concerns the gene PFKFB3 and neoplasm.