PFKFB3 and melanoma: For example, 3PO (first-in-class PFKFB3 inhibitor) is able to induce G2/M phase arrest in Jurkat cells (an immortalized line of human T lymphocyte cells) [12], whereas Kotowski et al. (2020) revealed that the 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) could also induce G0/1 phase cell cycle arrest in A375 human melanoma cells [107].