AEG-1 levels were undetectable or very low in all normal and BPH and gradually increased in PIN, primary tumors and metastasis with medium or high levels of expression in 10%, 47.2% and 80% cases, respectively, demonstrating a strong correlation of AEG-1 levels with clinical progression of the disease (p < 0.001) [34]. The gene discussed is MTDH; the disease is prostate intraepithelial neoplasia.