IHC analysis of 204 tissues, including 32 normal brain tissues, 80 Low-malignant astrocytomas (LMAs) and 92 High-Malignant astrocytomas (HMAs) showed AEG-1 positivity in 74.4% tumor samples which significantly correlated with histological grades (p < 0.001) [112]. This evidence concerns the gene MTDH and neoplasm.