MTDH and metastatic malignant neoplasm in the lymph nodes: While 6.8% normal tissues showed AEG-1 expression, in NSCLC cases it was 61.3% (p < 0.001) which showed significant association with TNM stage (p = 0.021), dedifferentiation (p = 0.034), vascular invasion (p = 0.035), lymph node metastasis (p < 0.001) and poor overall survival (p = 0.024) [44].