MTDH and cervical squamous intraepithelial neoplasia: IHC staining of normal cervical squamous epithelium revealed absence of AEG-1, while AEG-1 staining was positive in cervical intraepithelial neoplasia (CIN) I, II and III samples, indicating AEG-1 expression may necessitate progression of CIN to cervical carcinoma [66].