Western blot analysis of tissues from 9 normal individuals and 25 GBM, 18 astrocytomas, 18 meningiomas, 19 oligodendrogliomas and 18 other types of brain cancers revealed that compared to normal brain increased AEG-1 expression was detected in >90% glioma cases with a 3–10-fold increase, the highest being in GBM patients, which was supported by IHC analysis as well [110]. The gene discussed is MTDH; the disease is central nervous system cancer.