MTDH and central nervous system cancer: IHC in TMA revealed low levels of AEG-1 and Akt2 in normal brain samples and these levels showed progressive elevation in glioma samples from grade I to grade IV and a significant correlation was observed between AEG-1 and Akt2 levels in these samples (r2 = 0.9221) suggesting that AEG-1-Akt2 interaction plays a germane role in glioma pathogenesis [14].