MTDH and central nervous system cancer: IHC analysis of 296 glioma patients including 39 cases of grade 1 (13.2%), 121 cases of grade 2 (40.9%), 88 cases of grade 3 (29.7%) and 48 cases of grade 4 (16.2%) gliomas showed AEG-1 positivity in 89.5% cases, among which 48.3% were identified as low and 51.7% as high AEG-1 expression with a statistically significant difference in AEG-1 levels between normal brain and glioma samples (p < 0.001) [109].