These findings suggest that nuclear AEG-1 might protect from tumor formation, while cytoplasmic AEG-1 is more tumorigenic which is supported by studies in other cancers demonstrating a role of cytoplasmic AEG-1 in regulating miRNA function and protein translation contributing to tumorigenesis, chemoresistance and metastasis [10,21,22,23,24]. This evidence concerns the gene MTDH and cancer.