Cox multivariate analysis revealed that tumor size (>2 cm), lymph node metastasis, invasion as well as AEG-1 and EphA7 expression levels were negatively correlated with postoperative survival, and positively correlated with mortality suggesting that AEG-1 and EphA7 might be prognostic factors for GBC [95]. This evidence concerns the gene MTDH and metastatic malignant neoplasm in the lymph nodes.