MTDH and cancer: Indeed, overexpression of AEG-1 promotes all hallmarks of cancer and inhibition of AEG-1 reverses these phenotypes and tissue-specific AEG-1 transgenic mouse display augmented tumorigenesis and AEG-1 knockout mouse show resistance to the development and progression of multiple cancer types, such as those of liver, breast, prostate and colon, indicating that AEG-1 plays a pivotal role in regulating tumorigenesis [13,20,22,24,25,27,28,34,35,36].