IHC in 41 GBC, 10 adenomas and cholecystitis samples revealed gradual increase in AEG-1 staining intensity and frequency from normal mucosa to adenoma to GBC with 63.4% GBC samples showing AEG-1 overexpression (p = 0.0003 vs. cholecystitis) [94]. Here, MTDH is linked to Cholecystitis.