Analysis of tumor tissues, matched normal tissues and liver metastasis specimens from 520 CRC cases, which include 37 (7.12%), 204 (39.23%), 262 (50.38%) and 17 (3.27%) in Duke’s A, B, C and D clinical stages, respectively, revealed significantly higher AEG-1 expression in CRC with liver metastases [80]. Here, MTDH is linked to neoplasm.