CDH1 and neoplasm: A recent study using 71 GBC samples showed that high AEG-1 and low E-cadherin levels correlated with shorter OS and Cox multivariate analysis revealed that tumor TNM classification, histologic grade, lymphatic metastasis and AEG-1 and E-cadherin expression were independent factors for prognosis of GBC (p = 0.013, p = 0.019, p = 0.001, p = 0.011 and p = 0.025, respectively) [96].