TP53 and renal cell carcinoma: IHC analysis of AEG-1 and p53 in 50 RCC patients including 24 clear cell RCC, 12 papillary RCC, 4 multilocular cystic RCC and 10 chromophobe RCC without any sarcomatoid changes identified significant association of AEG-1 levels with tumor subtypes (p = 0.032), tumor capsule invasion (p = 0.01) and lymphovascular invasion (p = 0.015) [100].