IHC analysis in non-muscle-invasive bladder cancer (NMIBC) revealed high AEG-1 expression in 45% cases showing association with tumor grade (p = 0.002) and progression (p = 0.028), and shorter PFS (p = 0.0011) and multivariate analysis identified AEG-1 as a prognostic factor for patients with bladder cancer [103]. Here, MTDH is linked to neoplasm.