MTDH and rectal cancer: Rectal cancer patients showed higher AEG-1 expression than colon cancer patients (p = 0.047) and in a follow-up study of 158 rectal cancer patients treated with radiotherapy (RT), the authors documented that high AEG-1 expression in primary tumors independently correlated with higher risk of distant recurrence (p = 0.009) and worse DFS (p = 0.007), indicating that AEG-1 might be a marker to identify patients who might develop distant relapse [83].