Diagnostic accuracy of serum AEG-1 mRNA (AUC = 0.976) was significantly higher than other CRC screening markers, such as carcinoembryonic antigen (CEA), carbohydrate antigen 19.9 (CA19.9) and Fecal occult blood (FOB), and the combined accuracy of these markers (AUC = 0.741) was increased when used with serum AEG-1 mRNA (AUC = 0.820) [85]. The gene discussed is CEACAM5; the disease is colorectal carcinoma.