Among 15 CIN III samples, 11 (73.3%) were AEG-1 positive, while only 3 of 18 (16.7%) CIN I and 6 of 17 (35.3%) CIN II samples were AEG-1 positive indicating that AEG-1 expression is associated with grading of CIN [66]. This evidence concerns the gene MTDH and cervical squamous intraepithelial neoplasia.