MTDH and central nervous system cancer: AEG-1 interacts with MDM2 resulting in MDM2 stabilization [113] In 86 human glioma samples, IHC analysis revealed that AEG-1, MDM2 and Ki-67 expression levels progressively increased from grade II to grade IV and a positive correlation between AEG-1 and MDM2 expression was observed (p < 0.01) [113].