MTDH and cancer: AEG-1 functions as a scaffold protein and interacts with a variety of proteins and protein networks thereby activating key oncogenic pathways, such as NF-κB, PI3K/Akt, MEK/ERK, Wnt/β-catenin and TGF-β resulting in augmentation of all hallmarks of cancer, including proliferation, invasion, chemoresistance, angiogenesis and metastasis (Figure 2) [9,11,12,13,14,15,16,17].