IHC analysis of 85 HCC samples followed by univariate and multivariate analyses with Cox regression revealed that tumor size (HR, 2.285, 95% CI, p = 0.015), microvascular invasion (HR, 6.754, 95% CI, p = 0.008) and AEG-1 expression (HR, 4.756, 95% CI, p = 0.003) were independent prognostic factors for OS. Here, MTDH is linked to hepatocellular carcinoma.