A plethora of mechanisms dictate AEG-1 overexpression in cancers which include gene amplification, transcriptional regulation by c-Myc and NF-κB, posttranscriptional regulation by a variety of miRNAs and post-translational regulation by mono-ubiquitination and by cytoplasmic polyadenylation element-binding protein 1 (CPEB1) [10,13,23,30,31,32,33]. The gene discussed is CPEB1; the disease is cancer.