Importantly, the CL-HGSOC cell lines well recapitulate the transcriptional characteristics of human ovarian cancers, where the CL tumor cluster is characterized by extremely low expression of genes involved in cell junctional assembly and maintenance such as TACSTD, a paralogous gene of Ep-CAM, together with a massive down regulation of cytokeratins and the morphogenesis related genes GRHL2, SPINT2 and ST14, required to sustain epithelial cell lineage during embryonic development [46]. The gene discussed is SPINT2; the disease is ovarian cancer.