As the non-coding component is becoming increasingly relevant in the context of both obesity and cancer, closer attention was given to the implication of the six lncRNAs (SMIM25, ITGB2-AS1, COL4A2-AS2, CTEPHA1, ACER2-AS, RPS21-AS) that were found deregulated in OBF versus CTRL. This evidence concerns the gene PELATON and obesity due to melanocortin 4 receptor deficiency.