IZUMO1 and obesity due to melanocortin 4 receptor deficiency: Figure 1D shows the top 50 oncogenes for OBF vs. CTRL (blue), for OBT2D vs. CTRL (purple), for OBT2D vs. OBF (greens) and all the oncogenes emerging for OBM vs. OBF (red). The expression of a panel of genes, with a relevant OncoScore and FC, was analyzed via Real-Time PCR in an independent cohort of SAT samples obtained from normal-weight females, females affected by obesity, females affected by obesity and type 2 diabetes and males affected by obesity in order to support the validity of the RNA-seq analysis (Figure 1E).