In the same study [56] we also reported a positive association between the increase in number of MetS components and seminal interleukin 8 (sIL-8) levels, a marker of prostate inflammation [80,81,82], and with prostate volume and signs of inflammation evaluated with color-Doppler ultrasound [81,82,83,84], which represent other factors closely related to MetS [41,42,85]. This evidence concerns the gene CXCL8 and metabolic syndrome.