Conversely, the same group [58], investigating 167 men with secondary couple’s infertility, reported that patients with MetS (n = 20; NCEP-ATPIII criteria) showed lower semen volume, sperm concentration and normal morphology than patients without MetS (n = 147) and confirmed lower total testosterone (as well as inhibin B, SHBG and AMH) levels and a higher rate of hypogonadism in MetS men. The gene discussed is SHBG; the disease is Infertility.