In conclusion, RG attenuated BLM-induced pulmonary fibrosis in mice, inhibited myofibroblast activation and migration, and induced myofibroblast autophagy and apoptosis to downregulate ECM accumulation by suppressing the TGF-β1/Smad, TGF-β1/non-Smad, and mTOR signaling pathways. The gene discussed is MTOR; the disease is pulmonary fibrosis.