In a BLM mouse model of pulmonary fibrosis, BLM binding with ANXA2 impedes transcription factor EB (TFEB)-induced autophagic flux [27]; the inhibition of profibrotic cytokines induces autophagy flux and decreases the production of collagen to alleviate pulmonary fibrosis [28]. The gene discussed is ANXA2; the disease is pulmonary fibrosis.