The downregulation of pro-inflammatory cytokines such as IL-12p40, IL-23p19, TNF-α, and IL-1β, has also been described induced by endothelial cell-derived exosomes and the overexpression of immunosuppressive ones such as IL-10, MRC1 and TGF-β, to prevent damage and promote tissue regeneration favoring tumor growth and metastasis [35,36]. Here, TNF is linked to neoplasm.