Other similar observations followed, and Nicholson [39] and Sherrat [40] independently raised the concept of dystrophin rescue due to internal spontaneous exon skipping in DMD boys, providing, for the first time, an explanation of the revertant fiber event and introducing the concept of dystrophin protein restoration, today so popular in clinical trials [34,41,42]. This evidence concerns the gene DMD and Duchenne muscular dystrophy.