SLC5A2 and heart failure: While the exact mechanism, in addition to glycosuria, by which SGTL2 inhibitors are thought to reduce SUA levels is not well understood, the hypothesis that this effect is part of the CV and renal protection induced by SGLT2 inhibitors is evoked by the mediation analysis undertaken in EMPAREG OUTCOME, suggesting that changes in SUA mediated ~20% to 25% of the reduction in CV death and heart failure death seen with empagliflozin [34,35].