Importantly, we found that inflamed melanomas, with high CD3+ T-cells and CD8+ T-cells density or high CD8+ T-cells and CD68+ macrophagic infiltration, have a better prognosis when compared to those with desert melanomas characterized by low CD3+ and CD8+ T-cell density or low CD8+ T-cell and CD68+ macrophagic infiltration. Here, CD68 is linked to melanoma.