In order to narrow down our search and focus on gene regulatory networks of ETS proteins, we have identified overlapping genes by comparing DEGs from glioma grades 2–4 with the microarray results from Elk-1-VP16 and PEA3-VP16 overexpressing cells; 2637 genes were found to be at the intersections of these two experiments, with 63 genes commonly regulated in both glioma tumor samples (DEGs), as well as cell line studies (Elk-1-VP16 and PEA3-VP16) (Figure 2F). This evidence concerns the gene ETV4 and glioma.