Gene alterations, such as GSTP1 and GSTM1, glutathione-S-transferase genes and voltage-gated sodium channel genes SCN4A, SCN9A and SCN10A, together with pre-existing peripheral neuropathy [75,76,77,78] have been demonstrated to be the principal risk factors for OIPN onset. The gene discussed is GSTM1; the disease is peripheral neuropathy.