CUL5 and acromegaly: Preoperative acromegaly patients were characterized by higher levels of SOCS2 (1128.8 ± 471.0 pg/mL, p = 0.003), cullin-5 (60.99 ± 30.29 ng/mL, p = 0.001) and Rbx-2 (56.4 ± 31.1 pg/mL, p = 0.0002) compared to controls.