PRKCG and spinocerebellar ataxia type 14: Spinocerebellar ataxia type 14 (SCA14) [36] missense mutations in the PRKCG gene, which encodes the γ-isoform of protein kinase C (PKCγ), causes increased kinase activity, amyloid citotoxic aggregates and apoptosis via impairment of the ubiquitin proteasome system and induction of endoplasmic reticulum stress [73,74,75].