Compared to normal blood vessels, tumor blood vessels have larger fenestration along with high vascular permeability due to the extensively produced vascular mediators such as nitric oxide (NO), bradykinin (BK), vascular endothelial growth factor (VEGF), etc. These vascular mediators contribute to macromolecules’ selective entry and accumulation in tumor tissues [7,8,9]. The gene discussed is VEGFA; the disease is neoplasm.