In line with this, abrogation of mortalin-p53 complex by synthetic and natural molecules, including MKT-077, Mortaparib, withaferin A, withanone, cucurbitacin B, and fucoxanthin were shown to cause growth arrest and/or apoptosis of cancer cells in in vitro, and cause tumour growth suppression in in vivo assays [32,42,43,44,45]. This evidence concerns the gene TP53 and neoplasm.