TP53 and colorectal carcinoma: Then, in an attempt to elucidate one of the major oncogenic roles of mortalin in CRC, Gestl and Böttger [71] had previously concluded that mortalin inactivates the wild-type p53 protein through cytoplasmic sequestration in four CRC cell lines (HCT116, HT-29, LS123, and LoVo).