Indeed, the inability of tumor-infiltrating lymphocytes (TILs) to eradicate cancer could be attributed to many factors, such as their functional impairment, secondary to suppression induced by Tregs and other immune-suppression mechanisms, the lack of proper co-stimulation, or Major Histocompatibility Complex (MHC) down-regulation on the target cancer cells, resulting in evasion from immune recognition. Here, HLA-C is linked to cancer.