IFNG and neoplasm: Additionally, trifunctional fusion proteins composed of a tumor-specific recombinant antibody, RLI, and the extracellular region of co-stimulation molecules 4-1BBL, OX40L or glucocorticoid-induced TNF receptor ligand (GITRL), were effective in reducing lung metastasis in the B16-FAP melanoma mouse model, through the induction of T cell proliferation and cytotoxicity, and the secretion of IFN-γ [111,112].