Overall, these signaling pathways enhance the expression of genes involved in proliferation and anti-apoptotic signals such as Bcl-2, c-Myc, c-Fos, c-Jun, Mcl-1, Bcl-xl, in aerobic glycolysis, and in effector and cytotoxic immune cell functions and migration, such as IFN-γ, TNF-α, XCL1, Granzyme and Perforin. hetIL-15 effects on the immune system and the selectivity of hetIL-15 responsiveness makes this cytokine attractive for cancer immunotherapy. The gene discussed is IFNG; the disease is cancer.