Pregnancy is characterized by excess of circulating blood volume, secretion of sex-/growth- hormones, and immunosuppressive status: all these physiologic changes could favor cancer growth or progression [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42]. Here, PLXNA3 is linked to cancer.