RELN and cancer: In this context, RA mediates the upregulation of miR-128, which represses the expression of two factors involved in cell motility and in metastasis, Reelin and Dcx. Gain-of-function assays for this microRNA, and loss-of-function assays for the Reelin and Dcx genes, have shown lower cell mobility and migration, suggesting that this microRNA may exert a protective influence in cancer metastasis [106].