Comparing the Tg4 Teff pep data to data from the activation of T cells expressing the foreign-reactive TCRs 5C.C7 or DO11.10 with B cell lymphoma APCs and a high concentration of agonist peptide [15,18,21,46], comparable to the T cell activation conditions used here, central accumulation of LAT, DAG and TCRζ was diminished moderately in the Tg4 Teff pep cells. The gene discussed is CD247; the disease is B-cell non-Hodgkin lymphoma.