MMP9 and cancer: Several in vitro and in vivo studies reported that Rg3 impeded migration and invasion of ovarian (SKOV-3), lung (A549, H1299 and LLC1), pancreatic (tissues from cancer patients), colorectal (SW480 and Caco-2), thyroid (TPC-1, BCPAP, C643, and Ocut-2c), nasopharyngeal (HNE1 and CNE2), skin (B16), and breast (MCF-7) cancers via down-regulation of MMP-2 and/or MMP-9 [75,76,77,78,79,80,81,82,83,84,85].