Ginsenoside Rb1, which has multiple biological activities such anti-oxidant and anti-inflammatory effects, could suppress expression of collagenase MMP-13 in SW1353 human chondrosarcoma cells and SD rats with anterior cruciate ligament transection (80 μM), via inhibition of Notch molecular signaling pathways [103] (Figure 7). Here, MMP13 is linked to chondrosarcoma.