TIMP3 and colorectal cancer: Metastatic abilities of SW620 colorectal cancer cells were also suppressed by Rh1 (100 μM) via inhibition of MAPK signaling transduction pathways and transcriptions of MMP-1 and MMP-3 while increasing expression of tissue inhibitor of metalloproteinases 3 (TIMP3), a negative regulator of MMPs [93].