Inhibitors of DNA methyltransferases (DNMTi: 5-Aza, decitabine), histone deacetylases (HDACi: Vorinostat, Panobinostat, valproic acid, etc.)and histone methyltransferases (HMTi: EZH2 inhibitors -Tazemetostat) are undergoing clinical trials for cancer treatment with some being already approved [248]. The gene discussed is EZH2; the disease is cancer.