LMX1A and central nervous system cancer: Investigating the poor survival of glioma patients with high expression of the lncRNA SCAMP1 (Secretory carrier-associated membrane protein 1), this study showed that SCAMP-1 acts as a sponge for the miRNA miR499a-5p, thereby relieving its repressive effect on the LIM homeobox transcription factor 1, alpha (LMX1A) that binds the promoter region of the NLRC5 gene (Figure 3) at multiple sites (-1168, -1452, -1734 relative to TSS).