Subsequently, transfection of tumor cells with genes coding for cytokines that promote antigen presentation (discussed later), activate T cells and APC or induce costimulatory molecules (IFNγ, IL-2, IL-4, IL-7, GM-CSF) were shown to increase tumor immunogenicity and elicit antitumor immunity [34,35,36,37]. The gene discussed is IL4; the disease is neoplasm.