As NLRC5 is the most frequently affected MHC-I pathway gene in many human cancers, and NLRC5 expression positively correlates with patient survival in several cancers including melanoma, cervical cancer and bladder cancer, Yoshihama et al., proposed NLRC5 as a potential prognostic biomarker for tumor immune evasion [28]. The gene discussed is NLRC5; the disease is cancer.