Modulation of the epigenetic signature at the NLRC5 promoter is also implicated in STAT1-independent upregulation of NLRC5 and MHC-I genes in pancreatic cancer cells exposed to ionizing radiation, although an earlier report attributed radiation-induced MHC-I upregulation in breast cancer cell lines to secretion of IFNβ [183,184]. The gene discussed is NLRC5; the disease is familial pancreatic carcinoma.