Increased CpG methylation of the NLRC5 and other IFN-I-responsive genes was reported in the genomic DNA of systemic lupus erythematosus patients that correlated with increased auto-antibody production, suggesting that epigenetic modulation of NLRC5 may also be influenced by systemic inflammation [185].Moreover, the chicken NLRC5 gene was reported to harbor two CpG islands, one near the proximal core promoter that is unmethylated, and the second one encompassing an additional STAT1 binding site (distal to the STAT1-NF-κB site) that could be methylated [186]. Here, STAT1 is linked to systemic lupus erythematosus.