PSEN2 and ischemia: It shows changes in proteins and their genes expression, i.e., the amyloid protein precursor, β-secretase, presenilin 1, presenilin 2, and tau protein in rats following ischemia in the CA1 region of the hippocampus, as well as genes involved in the death of neurons after ischemia in the hippocampus, i.e., autophagy, mitophagy, and apoptosis. Data show that ischemia causes the death of pyramidal neurons in the hippocampus in an amyloid-dependent manner (Figure 1).