The clear reduction of the expression of migration- and invasion-related genes PAXILLIN, VINCULIN, CORTACTIN and WASF-1 upon KAN0438757 treatment was observed exclusively in HUVECs, suggesting that (i) in cancer cells other molecular mechanisms might be involved in their diminished motility capabilities (ii) or/and unknown compensatory mechanisms triggered by KAN0438757 treatment. This evidence concerns the gene CTTN and cancer.