PFKFB3 and neoplasm: Recently, it has been shown that tumor endothelial cells are highly dependent on glycolysis for angiogenesis and survival, and that indirect blockade of glycolysis by administration of the PFKFB3 inhibitor 2E-3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) was able to induce tumor vessel normalization (TVN), normalizing the structure and function of the highly abnormal tumor vessels [5].