PFKFB3 and cancer: Our findings that the new PFKFB3 inhibitor was able to robustly affect HCT-116 and HT-29 cancer cells viability in a concentration-dependent manner, without profound effects on induced-cell death in HUVECs and normal colon epithelial cells are in accordance with what was previous suggested by Gustafsson and colleagues [6] that normal, non-transformed and less proliferating cells would present higher tolerability to KAN0438757 at concentrations which can disrupt cancer cell survival.