PFKFB3 and cancer: Initial comparative analyses from two different large CRC patient cohorts (The Cancer Genomic Atlas Network cohort for colon cancer [20] and a rectal cancer cohort from our clinic, RRID:SCR_007834 oncomine.org) revealed that PFKFB3 mRNA expression is found significantly increased in both colon and rectal adenocarcinoma compared to normal mucosa (Figure 1A,B).