KIT and mastocytosis: To identify autocrine/paracrine effects of tryptase on these cells, further studies need to include in vitro experiments with KIT D816V+ mast cell lines, cultured cord-blood cell-derived mast cells, induced pluripotent stem cells derived from KIT D816V+ HαT+ mastocytosis patients and primary patient samples as well in vivo experiments with murine xenotransplant models.