THBD and infection: These genes were categorized in three groups according to their basal activity and inducibility: group 1 (CAMP, CD14, FN1, TREM1) includes proteins related to acute response to infection, with low basal expression but high inducibility, group 2 (LILRB4, LRRC25, MAPK13, SEMA6B, THBD, THEMIS2) refers to proteins involved in general response to infection, with intermediate responsiveness to transcriptome and epigenome level, and group 3 (ACVRL1, CD93, CEBPB, NINJ1, SRGN) is represented by proteins related to autoimmunity, with high basal activity and low inducibility genes [18].