The interactome of EphA2 is complex, and focus thus far has been on proteins within the cytosolic compartment or at the plasma membrane, where two recent reports have identified PLCγ1 as well as VEGFR2 to form a complex with EphA2 influencing NSCLC cell survival and also metastatic potential [33,34]. The gene discussed is EPHA2; the disease is non-small cell lung carcinoma.