Our results are not in contradiction to earlier reports on the EphA2 interactors as indicated above but illustrate that, in addition to those interactions between EphA2 and membrane bound proteins, i.e., VEGFR2 [34], which influence NSCLC metastatic signaling, EphA2 may also impact on IR responses by influencing DDR. This evidence concerns the gene EPHA2 and non-small cell lung carcinoma.