JAK2 and deep vein thrombosis: Among these, positivity for antiphospholipid antibodies, including anticardiolipin antibodies and lupus anticoagulant [49,50], as well as the prothrombin gene mutation G20210A [51], the C677 > T substitution in the methylenetetrahydrofolate reductase gene (a mutation that causes increased plasma levels of homocysteine) [52], and JAK2 and factor V Leiden mutations [53], have been reported to be correlated with DVT risk.