Consistently, in studies conducted in myostatin-deficient ApcMin/+ mice and in LLC hosts [12,105], as well as in inhibin-α-deficient mice with gonadal tumors [10,110] and in a murine model of pancreatic ductal adenocarcinoma [146], blockade of ACVR2B ligands or signaling also resulted in partial attenuation of tumor growth and/or metastasis formation, which, in turn, may contribute to alleviation of cachexia and prolonged survival. The gene discussed is ACVR2B; the disease is neoplasm.