ACVR2A and neoplasm: Mechanistically, blocking ACVR2 signaling using sACVR2B was able to restore [35] or attenuate [169] decreased muscle protein synthesis and decreased mTOR colocalization with late-endosomes/lysosomes in C26 tumor-bearing mice [13], in line with the increased muscle protein synthesis observed after acute administration of sACVR2B in healthy wild-type mice [161].