Likewise, osthol administration (OT30 and OT40) partially prevented tubular damage measured by N-acetyl-β-D-glucosaminidase (NAG) and neutrophil gelatinase associated-lipocalin (NGAL) urine excretion, as well as kidney injury molecule (KIM)-1 expression in comparison to C and HF/HS groups (Figure 2B). This evidence concerns the gene LCN2 and hydrops fetalis.