COL1A1 and cancer: Furthermore, we have identified a fibrotic phenotype of the cancer free pAT characterised by up-regulation of COL1A1. Additionally, we have shown up regulation of SFRP2, a mesenchymal and pre-adipocyte marker, and also a pro-fibrotic gene involved in collagen production, exhibiting pro-collagenase enhancing activity of Tolloid-like metalloproteinases [67].