In HFD-fed mice injected with either Met-1 or TC2 tumor cells, the total CD45+CD11b+ myeloid lineage cell population was significantly increased compared to LFD-fed mice (Figure 2d), indicating that obesity enhances myeloid cell recruitment during metastatic outgrowth. The gene discussed is ITGAM; the disease is obesity due to melanocortin 4 receptor deficiency.