In Non-small cell lung cancer (NSCLC) cells, it was observed that DKK3 overexpression inhibits the growth of NSCLC cells by inducing apoptosis and cell cycle disturbance by transactivating c-myc and cyclin D1 through β-catenin/TCF-4 signaling [35]. This evidence concerns the gene TCF4 and non-small cell lung carcinoma.