It has been identified that DKK3 downregulates key proteins in non-canonical Wnt pathway such as c-Jun N-terminal kinase (JNK), Ca2+/calmodulin-dependent protein kinase II (CAMKII), and histone deacetylase 4 (HDAC4) in familial dilated cardiomyopathy [5]. The gene discussed is HDAC4; the disease is familial dilated cardiomyopathy.