CASP3 and acute myeloid leukemia: Here we show that MEDS433 also has a strong pro-apoptotic effect on several AML cell lines, as demonstrated by: (i) the Annexin V assay (Figure 1); (ii) the increased caspase-3/7 activity (Figure 2A) and the increased levels of cleaved caspase 3 (Figure 2B and Figure S8) after exposure to MEDS433; (iii) the reduction in apoptosis when experiments were performed in the presence of a caspase inhibitor (Z-VAD-fmk, data not shown); and (iv) the morphologic evaluation of cells treated with MEDS433 (Figure 2C).