In order to mimic more closely the human setting, we substituted AML cell lines with AML primary cells: again, while dipyridamole, MEDS433 or teriflunomide alone could not induce apoptosis, the combination of either DHODH inhibitor with dipyridamole resulted in a strong synergistic effect (Figure 9A,B). Here, DHODH is linked to acute myeloid leukemia.