The salvage mechanism probably justifies the low toxicity of DHODH inhibitors in non-proliferating cells; on the other hand, it represents a natural escape that cancer cells can leverage to survive; uridine, indeed, is naturally present in plasma and can enter the cells through Equilibrative Nucleoside Transporters (hENT1/2) or, to a lesser extent, Concentrative Nucleoside Transporters (hCNT) channels. This evidence concerns the gene DHODH and cancer.